Spotlight: Adrenal IV Drips
So, I've covered what adrenal fatigue is and how phosphatidylserine could help with adrenal fatigue. Didn't read my posts? It's cool, I'm not mad. But here's a summary for you... Quick recap: chronic stress can lead to suboptimal cortisol output by the adrenal glands (glands that are located just above the kidneys), which can then lead to chronic fatigue, sleeping issues, mood symptoms, reduced sex hormones, and salt and sugar cravings. Sound like you? Don't worry, it's basically a majority of us nowadays. So, you're not alone!
Solutions? One is phosphatidylserine, and it helps balance stressed-out adrenal glands by modulating how much cortisol is released. Other natural solutions are vitamins and minerals, which are needed to support healthy adrenal function... And, that's where Jupiter-exclusive IV nutrient drips come in.
IV Adrenal Drip 1: Early-stage Adrenal Fatigue
What's in it?
The important actives found in IV Adrenal Drip 1 are:
3 grams of Vitamin C
What does science say?
Magnesium helps relax smooth and skeletal muscle. Studies show that a majority of the magnesium found in the body is found in muscle tissue, indicating its importance for those areas. Why care about muscle relaxation? Well, muscle relaxation sends signals to the brain to help reduce mental stress. When muscle relax, the brain relaxes. Also, it helps reduce muscle pains and cramps (which can act as physical stressors to the body) and can also help reduce blood pressure. Studies also show that when the body is pathologically depleted of magnesium, it can lead to a variety of symptoms that impact the whole body. The condition is called hypomagnesemia, and some of the symptoms include:
High blood pressure
So, not only is magnesium helpful for muscle and heart relaxation, but it's also helpful in so many other processes in the body.
Calcium has been shown to increase adrenal gland sensitivity to a hormone called ACTH in animal models. ACTH is a hormone sent out by the brain when a stressful event takes place, which then activates the adrenal glands to send out cortisol. In animal models, the animal analog of human cortisol is called corticosterone. And in an animal study investigating the effects of calcium on ACTH, researchers found that ACTH is directly proportional to calcium levels in subjects and that corticosterone production was dependent upon calcium levels in subjects.
Dexpanthenol is a provitamin to pantothenic acid (Vitamin B5), basically meaning that dexpanthenol become B5 in the body. Studies show that B5 helps stimulate adrenal glands in animal models to produce corticosterone. Animal models also indicate that B5 increased adrenal response from brain signals to produce corticosterone. So, not only does B5 work with producing corticosterone in animal models, but is also helps the adrenals become more responsive to brain signals so that it can optimally send out corticosterone.
Methyl-B12 + Folic Acid
Methyl-B12 and folic acid are B-vitamins vital in the production of cellular energy. These two vitamins are used by mitochondria in cells to make ATP - the fuel for healthy cellular function. By adding in these two vitamins, the goal is to replete the body of cofactors for ATP to help promote optimal cellular function during chronic stress.
The adrenals glands have the highest concentration of Vitamin C in the body, and research shows that Vitamin C plays a role in adrenal hormone production. One study done on subjects undergoing cardiac surgery investigating the effect of Vitamin C supplementation before taking an adrenal-suppressing drug showed that those who took Vitamin C before taking the adrenal-suppressing medication had higher amounts of cortisol in their bodies compared to those who took a placebo before taking the adrenal-suppressing medication. This same study showed that those who took the placebo had consistently lower levels of cortisol in their system during the first 24 hours after taking the adrenal-suppressing medication compared to those who took Vitamin C.
Relax Drip Research Takeaways
So, in so many words, and with so many research references, the Jupiter IV Adrenal Drip 1 aims to relax the body and replete the body of vital nutrients to support and maintain optimal cellular function during the first stage of adrenal dysfunction. Think of it as a multivitamin specifically for your adrenals. So, if you've been stressed out for a few weeks-months, this drip is going to be your bestie.
IV Adrenal Drip 2: Late-stage Adrenal Fatigue
What's in it?
The Adrenal Drip 2 has the same actives in the IV Adrenal Drip 1, but there are more adrenal-nourishing and energy-boosting nutrients. These nutrients are:
IV Relax nutrients (magnesium, calcium, Dexpanthenol, Methyl-B12, Folic Acid)
4 grams of Vitamin C
What does science say?
Research investigating the impacts of pharmaceutical adrenal suppression in varying doses with concurrent zinc supplementation on depression in animal models show that zinc has a role in modulating depressive-like behaviors. So, why care about this one bit of info? Well, adrenal suppression can be similar to adrenal dysfunction after years of chronic stress, where the adrenal glands sub-optimally produce and release cortisol hormone. Also, zinc has been shown to have an impact on mood by modulating excitatory and inhibitory neural signals in the brain. The specific modulation detailed in a review article is that zinc reduces the action of excitatory neurons to cause an "antidepressant" effect.
L-carnitine is an amino acid that is vital to mitochondrial function to help make ATP, the fuel for cell function. How does L-carnitine do this? This amino acid helps mitochondria use long-chain fatty acids to make cellular energy. So, with the combination of energy-supporting methyl-B12 and folic acid, L-carnitine can help support healthy cellular function by supporting the mitochondria to produce ATP.
Taurine is an amino acid that can act like a neurotransmitter in the body. Studies show that it has highest concentrations in the heart and in skeletal muscle. Why? It plays a vital role in maintaining healthy heart muscle and skeletal muscle contractility by maintaining necessary concentrations of electrolytes. In addition to that, taurine has been shown to impact cortisol through GABA receptor binding to reduce anxiety. Okay, why care about this? Anxiety could add to adrenal dysfunction by activating stress pathways. Remember, stress means both physical and mental stress. So, by reducing anxiety through GABA receptor activation, Taurine could help reduce maladaptive cortisol output, which could be beneficial for late-stage adrenal dysfunction.
This formula has the highest amount of Vitamin C given via IV safely before needing testing for G6PD. Any dosage higher than this can cause health problems for those with G6PD deficiency (which is why testing is always needed for high-dose Vitamin C drips). With this higher dosage of Vitamin C compared to the relax drip, the adrenal glands have the potential the become even more nourished to recharge and have the potential to send out cortisol hormone optimally.
Energy Drip Research Takeaways
By combining the IV Relax Drip nutrients with Zinc, L-carnitine, Taurine, and more Vitamin C in the Jupiter IV Energy Drip, the adrenals become more nourished, the body has the potential to make more cellular energy, and the mind is able to balance out mental stressors that could contribute to further adrenal dysfunction.
With the Adrenal Drip 1 being considered as a multivitamin for the adrenals, think of the Adrenal Drip 2 as a step-up to that since it has more-advanced nutrients to support optimal adrenal function. I basically like to think of this drip as the CEO drip, since stressed-out CEOs will greatly benefit from this nutritional drip. So, if you're a CEO or deeper in adrenal fatigue, the Adrenal Drip 2 will be your go-to.
There ya' go. Two modern natural solutions to help with the different stages of adrenal fatigue. Not too sure which stage you're in? Schedule your baseline naturopathic consultation with me, and we can figure it out. In the 90-minutes that we have, I will do an in-depth medical history, do bioenergetic muscle testing, and do conventional physical exams to guide and formulate your personalized naturopathic treatment plan. Your treatment plan will include advanced functional labs to assess adrenal function and we may even look at your sex hormones and thyroid hormone to see why you're so tired all the time. Beyond that, herbs, nutrients, and even an IV drip regiment may be prescribed. Remember, naturopathic medicine has many treatment options, and we formulate natural treatment plans based upon a variety of factors to make sure that your treatment is as successful as it can be.
- Dr. B
Bowyer, Frank, and Abbas E. Kitabchi. “Dual Role of Calcium in Steroidogenesis in the Isolated Adrenal Cell of Rat.” Biochemical and Biophysical Research Communications, vol. 57, no. 1, 1974, pp. 100–105., doi:10.1016/s0006-291x(74)80362-1.
Das, Deepanwita, et al. “Effect of Vitamin C on Adrenal Suppression by Etomidate Induction in Patients Undergoing Cardiac Surgery: A Randomized Controlled Trial.” Annals of Cardiac Anaesthesia, vol. 19, no. 3, 2016, p. 410., doi:10.4103/0971-9784.185522.
Gourgoulianis, K.i., et al. “Magnesium as a Relaxing Factor of Airway Smooth Muscles.” Journal of Aerosol Medicine, vol. 14, no. 3, 2001, pp. 301–307., doi:10.1089/089426801316970259.
Houten, Sander Michel, and Ronald J. A. Wanders. “A General Introduction to the Biochemistry of Mitochondrial Fatty Acid Î²-Oxidation.” Journal of Inherited Metabolic Disease, vol. 33, no. 5, 2010, pp. 469–477., doi:10.1007/s10545-010-9061-2.
Jaroenporn, Sukanya, et al. “Effects of Pantothenic Acid Supplementation on Adrenal Steroid Secretion from Male Rats.” Biological & Pharmaceutical Bulletin, vol. 31, no. 6, 2008, pp. 1205–1208., doi:10.1248/bpb.31.1205.
Kitabchi, Abbas E. “Ascorbic Acid in Steroidogenesis.” Nature, vol. 215, no. 5108, 1967, pp. 1385–1386., doi:10.1038/2151385a0.
Lv, Qiufeng, et al. “Effects of Taurine on ACE, ACE2 and HSP70 Expression of Hypothalamic-Pituitary-Adrenal Axis in Stress-Induced Hypertensive Rats.” Advances in Experimental Medicine and Biology Taurine 10, 2017, pp. 871–886., doi:10.1007/978-94-024-1079-2_69.
Müller, D.m., et al. “Effects of Oral L-Carnitine Supplementation on in Vivo Long-Chain Fatty Acid Oxidation in Healthy Adults.” Metabolism, vol. 51, no. 11, 2002, pp. 1389–1391., doi:10.1053/meta.2002.35181.
Mlyniec, Katarzyna. “Zinc in the Glutamatergic Theory of Depression.” Current Neuropharmacology, vol. 13, no. 4, 2015, pp. 505–513., doi:10.2174/1570159x13666150115220617.
Navabi, Seyedeh Parisa, et al. “Zinc Chloride Reverse Influence on Dexamethasone Depressant Effects in Adult Male Rats.” Jentashapir Journal of Health Research, vol. 6, no. 6, 2015, doi:10.17795/jjhr-24297.
Pan, Lingmei, et al. “Effects of Pantothenic Acid Supplement on Secretion of Steroids by the Adrenal Cortex in Female Rats.” Reproductive Medicine and Biology, vol. 11, no. 2, 2011, pp. 101–104., doi:10.1007/s12522-011-0113-6.
Patak, P., et al. “Vitamin C Is an Important Cofactor for Both Adrenal Cortex and Adrenal Medulla.” Endocrine Research, vol. 30, no. 4, 2004, pp. 871–875., doi:10.1081/erc-200044126.
Rafalo, Anna, et al. “Zinc Deficiency and Depression.” Nutritional Deficiency, 2016, doi:10.5772/63210.
Stachowicz, Marta, and Anna LebiedziÅska. “The Effect of Diet Components on the Level of Cortisol.” European Food Research and Technology, vol. 242, no. 12, 2016, pp. 2001–2009., doi:10.1007/s00217-016-2772-3.
Swaminathan, R. “Magnesium Metabolism and Its Disorders.” The Clinical Biochemist Reviews 24.2 (2003): 47–66. Print.
Wu, Jang-Yen. “Role of Taurine in the Central Nervous System.” Journal of Biomedical Science, vol. 10, 24 Aug. 2010.
DISCLAIMER: These statements have not been evaluated by the Food and Drug Administration. There are no financial ties to any supplement companies, pharmaceutical companies, or to any of the products mentioned in this post. This post is not meant to treat, cure, prevent, or diagnose conditions or diseases and is meant for educational purposes. As always, please consult your doctor before trying any new treatments or supplements.